5inch.com is a Chicago-based company that carries awesomely designed CD-Rs, DVD-Rs and cases. If you are willing to order at least 500, they also offer custom print jobs. Each of their printed CD-Rs are silk-screened in a limited run, so once the design is gone, it's gone.
I ordered 25 sets (triggercase + CD-R) of these for a Christmas mix for friends and family a few years ago and was very pleased with the CD-Rs. They definitely made the gifts stand out over the typical sharpie magic. I can't really recommend the triggercases though. While the look stands out, I found that shoving a CD-R back and forth across the opening caused light scratching.
Use them for mixes as presents or for you web designers, send one to a client with a backup of their site when you're done, for that extra oomph. I think a best bet is their Sampler Pack where you can pick out 10 different designs for $15.